Aryl hydrocarbon hydroxylase (AHH) induction by polybrominated biphenyls (PBBs): Enhancement by photolysis
Identifieur interne : 005173 ( Main/Exploration ); précédent : 005172; suivant : 005174Aryl hydrocarbon hydroxylase (AHH) induction by polybrominated biphenyls (PBBs): Enhancement by photolysis
Auteurs : Larry W. Robertson [États-Unis] ; Andrew Parkinson [Canada] ; Brock Chittim [Canada] ; Stelvio Bandiera [Canada] ; Thomas W. Sawyer ; Stephen Safe [États-Unis, Canada]Source :
- Toxicology [ 0300-483X ] ; 1981.
Abstract
Irradiation of the commercial polybrominated biphenyl (PBB) mixture, fireMaster BP-6, in cyclohexane solution at 300 nm for 930 min resulted in a marked diminution of the major components of the mixture. Administration of the photolyzed PBB mixture or fireMaster BP-6 to immature mall Wistar rats caused dose-related decreases in thymus weight and increases in hepatic microsomal benzo[a]pyrene hydroxylase (AHH), 4-dimethylaminoantypyrine N-demethylase and NADPH-cytochrome c reductase activities and cytochrome P-450 content. The dose effecting half-maximal AHH induction for the photolyzed PBBs (9 mg · kg−1) was approximately 6 times lower than that of fireMaster Bp-6 (50 mg · kg−1). Futhermore, the concentration of photolyzed PBBs (2 μM) required to displace 50% of the specifically-bound [3H]TCDD from its high-affinity cytosolic Ah receptor was approximately 150 times lower than that required for fireMaster BP-6 (300 μM), as measured by sucrose density gradient centrifugation analysis. The results suggest that the photolysis of the commercial PBB mixture yields products which possess increased biologic activity.
Url:
DOI: 10.1016/0300-483X(81)90110-4
Affiliations:
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Administration of the photolyzed PBB mixture or fireMaster BP-6 to immature mall Wistar rats caused dose-related decreases in thymus weight and increases in hepatic microsomal benzo[a]pyrene hydroxylase (AHH), 4-dimethylaminoantypyrine N-demethylase and NADPH-cytochrome c reductase activities and cytochrome P-450 content. The dose effecting half-maximal AHH induction for the photolyzed PBBs (9 mg · kg−1) was approximately 6 times lower than that of fireMaster Bp-6 (50 mg · kg−1). Futhermore, the concentration of photolyzed PBBs (2 μM) required to displace 50% of the specifically-bound [3H]TCDD from its high-affinity cytosolic Ah receptor was approximately 150 times lower than that required for fireMaster BP-6 (300 μM), as measured by sucrose density gradient centrifugation analysis. The results suggest that the photolysis of the commercial PBB mixture yields products which possess increased biologic activity.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Sawyer, Thomas W" sort="Sawyer, Thomas W" uniqKey="Sawyer T" first="Thomas W." last="Sawyer">Thomas W. Sawyer</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Robertson, Larry W" sort="Robertson, Larry W" uniqKey="Robertson L" first="Larry W." last="Robertson">Larry W. Robertson</name></noRegion><name sortKey="Safe, Stephen" sort="Safe, Stephen" uniqKey="Safe S" first="Stephen" last="Safe">Stephen Safe</name></country><country name="Canada"><noRegion><name sortKey="Parkinson, Andrew" sort="Parkinson, Andrew" uniqKey="Parkinson A" first="Andrew" last="Parkinson">Andrew Parkinson</name></noRegion><name sortKey="Bandiera, Stelvio" sort="Bandiera, Stelvio" uniqKey="Bandiera S" first="Stelvio" last="Bandiera">Stelvio Bandiera</name><name sortKey="Chittim, Brock" sort="Chittim, Brock" uniqKey="Chittim B" first="Brock" last="Chittim">Brock Chittim</name><name sortKey="Safe, Stephen" sort="Safe, Stephen" uniqKey="Safe S" first="Stephen" last="Safe">Stephen Safe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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